BDBM50331115 2-(pyrrolidin-1-yl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine::CHEMBL1289500::US9422293, 106::US9738649, Example 106

SMILES FC(F)(F)c1ccc(Nc2nc(nc3CCN(CCc23)c2ncccc2C(F)(F)F)N2CCCC2)cc1

InChI Key InChIKey=RVTWSZCNDNZGLF-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50331115   

TargetTransient receptor potential cation channel subfamily V member 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50331115(2-(pyrrolidin-1-yl)-N-(4-(trifluoromethyl)phenyl)-...)
Affinity DataIC50:  5.40nMT: 37°CAssay Description:HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...More data for this Ligand-Target Pair
In DepthDetails US Patent


LigandPNGBDBM50331115(2-(pyrrolidin-1-yl)-N-(4-(trifluoromethyl)phenyl)-...)
Affinity DataIC50:  62nMT: 37°CAssay Description:The assay was performed as described below, using HEK293 cells transfected with rat TRPV1 (rTRPV1/HEK293). These cells had a geneticin selection mark...More data for this Ligand-Target Pair
In DepthDetails US Patent


LigandPNGBDBM50331115(2-(pyrrolidin-1-yl)-N-(4-(trifluoromethyl)phenyl)-...)
Affinity DataIC50:  62nMAssay Description:The assay was performed as described above, using HEK293 cells transfected with rat TRPV1 (rTRPV1/HEK293). These cells had a geneticin selection mark...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetTransient receptor potential cation channel subfamily V member 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50331115(2-(pyrrolidin-1-yl)-N-(4-(trifluoromethyl)phenyl)-...)
Affinity DataIC50:  5.40nMAssay Description:HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetTransient receptor potential cation channel subfamily V member 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50331115(2-(pyrrolidin-1-yl)-N-(4-(trifluoromethyl)phenyl)-...)
Affinity DataIC50:  61nMAssay Description:Antagonist activity at human recombinant TRPV1 assessed as inhibition of capsaicin-induced in intracellular calcium levels by cell-based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed