BDBM50331727 CHEMBL1289203::N-(2-((3S,4S)-4-ethoxy-1-(cis-4-hydroxy-4-p-tolylcyclohexyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide

SMILES CCO[C@H]1CN([C@H]2CC[C@@](O)(c3ccc(C)cc3)CC2)C[C@@H]1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1

InChI Key InChIKey=JQPQRYDIQFLFAA-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50331727   

TargetC-C chemokine receptor type 2(Human)
Incyte

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50331727BDBM50331727(N-(2-((3S,4S)-4-ethoxy-1-(cis-4-hydroxy-4-p-tolylc...)
Affinity DataIC50: 1.40nMAssay Description:Antagonist activity at human CCR2 assessed as inhibition of MCP1 induced chemotaxis after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Mouse)
Incyte

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50331727BDBM50331727(N-(2-((3S,4S)-4-ethoxy-1-(cis-4-hydroxy-4-p-tolylc...)
Affinity DataIC50: 2.10nMAssay Description:Displacement of [125I]MCP1 from mouse CCR2 after 30 mins by gamma counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Incyte

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50331727BDBM50331727(N-(2-((3S,4S)-4-ethoxy-1-(cis-4-hydroxy-4-p-tolylc...)
Affinity DataIC50: 2.30nMAssay Description:Displacement of [125I]MCP1 from human CCR2 after 30 mins by gamma counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Mouse)
Incyte

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50331727BDBM50331727(N-(2-((3S,4S)-4-ethoxy-1-(cis-4-hydroxy-4-p-tolylc...)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at mouse CCR2 assessed as inhibition of MCP1 induced chemotaxis after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50331727BDBM50331727(N-(2-((3S,4S)-4-ethoxy-1-(cis-4-hydroxy-4-p-tolylc...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed