BDBM50331728 CHEMBL1289316::N-(2-((3S,4S)-1-(cis-4-(benzo[d][1,3]dioxol-5-yl)-4-hydroxycyclohexyl)-4-ethoxypyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide
SMILES CCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@H]1CC[C@](O)(CC1)c1ccc2OCOc2c1
InChI Key InChIKey=MZEOSVPWMSEFPW-UTWBDPIXSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 13 hits for monomerid = 50331728
Affinity DataIC50: 5.10nMAssay Description:Displacement of [125I]MCP1 from human CCR2 after 30 mins by gamma counterMore data for this Ligand-Target Pair
Affinity DataIC50: 9.5nMAssay Description:Displacement of [125I]MCP1 from mouse CCR2 after 30 mins by gamma counterMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of mouse CCR5More data for this Ligand-Target Pair
Affinity DataIC50: 3.80nMAssay Description:Antagonist activity at human CCR2 assessed as inhibition of MCP1 induced chemotaxis after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 7.80nMAssay Description:Displacement of [125I]MCP1 from mouse CCR2 after 30 mins by gamma counterMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Affinity DataKd: 0.720nMAssay Description:Displacement of [3H]INCB3344 from human CCR2 receptor expressed in human U2OS cell membranes assessed as association and dissociation of compound by ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of cynomolgus CCR2More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of mouse CCR1More data for this Ligand-Target Pair
Affinity DataKd: 0.900nMAssay Description:Displacement of [3H]INCB3344 from human CCR2 receptor expressed in human U2OS cell membranes by saturation binding assayMore data for this Ligand-Target Pair
Affinity DataKd: 1.20nMAssay Description:Displacement of [3H]INCB3344 from human CCR2 receptor expressed in human U2OS cell membranesMore data for this Ligand-Target Pair
Affinity DataKd: 0.230nMAssay Description:Displacement of [3H]INCB3344 from human CCR2 receptor expressed in human U2OS cell membranes assessed as association and dissociation of radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of rat CCR2More data for this Ligand-Target Pair