BDBM50332484 CHEMBL1630111::N-(2-aminophenyl)-5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carboxamide

SMILES Nc1ccccc1NC(=O)c1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1

InChI Key InChIKey=DWLVUAOJOFAURW-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50332484   

TargetEpidermal growth factor receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332484(N-(2-aminophenyl)-5-(4-(3-chloro-4-(3-fluorobenzyl...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of EGFR by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332484(N-(2-aminophenyl)-5-(4-(3-chloro-4-(3-fluorobenzyl...)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of HER2 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetInsulin receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332484(N-(2-aminophenyl)-5-(4-(3-chloro-4-(3-fluorobenzyl...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of INSR by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332484(N-(2-aminophenyl)-5-(4-(3-chloro-4-(3-fluorobenzyl...)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of PLK1 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332484(N-(2-aminophenyl)-5-(4-(3-chloro-4-(3-fluorobenzyl...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of PDGFRbeta by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332484(N-(2-aminophenyl)-5-(4-(3-chloro-4-(3-fluorobenzyl...)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of ABL1 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332484(N-(2-aminophenyl)-5-(4-(3-chloro-4-(3-fluorobenzyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant HDAC6 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332484(N-(2-aminophenyl)-5-(4-(3-chloro-4-(3-fluorobenzyl...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CDK2 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332484(N-(2-aminophenyl)-5-(4-(3-chloro-4-(3-fluorobenzyl...)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of Flag tagged human recombinant HDAC8 expressed in Sf21 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332484(N-(2-aminophenyl)-5-(4-(3-chloro-4-(3-fluorobenzyl...)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of Flag tagged human recombinant HDAC3 expressed in Sf21 cells coexpressing SMRT DAD domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332484(N-(2-aminophenyl)-5-(4-(3-chloro-4-(3-fluorobenzyl...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human recombinant HDAC1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed