BDBM50332593 CHEMBL1630789::cis-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(3-methylisothiazol-5-yl)piperidine-1-carboxamide

SMILES Cc1cc(NC(=O)N2CC[C@@H](C)[C@@H](N(C)c3ncnc4[nH]ccc34)C2)sn1

InChI Key InChIKey=XZXYNRDSRVDEFY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50332593   

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50332593BDBM50332593(cis-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-...)
Affinity DataIC50: 26nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50332593BDBM50332593(cis-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-...)
Affinity DataIC50: 510nMAssay Description:Inhibition of GST-tagged human JAK2 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50332593BDBM50332593(cis-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-...)
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of GST-tagged human JAK1 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed