BDBM50334106 (3-((3-chlorophenyl)ethynyl)-4-methoxyphenyl)(4-(pyrimidin-4-yl)piperazin-1-yl)methanone::CHEMBL1645018

SMILES COc1ccc(cc1C#Cc1cccc(Cl)c1)C(=O)N1CCN(CC1)c1ccncn1

InChI Key InChIKey=MTJPYUMSXZZZOW-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50334106   

TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50334106((3-((3-chlorophenyl)ethynyl)-4-methoxyphenyl)(4-(p...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]-MPEP from rat mGluR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50334106((3-((3-chlorophenyl)ethynyl)-4-methoxyphenyl)(4-(p...)
Affinity DataIC50:  66nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293 cells assessed as inhibition of L-glutamate-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed