BDBM50335201 5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine::CHEMBL1231124

SMILES C[C@H](Nc1ncc(Cl)c(Nc2cc(C)n[nH]2)n1)c1ncc(F)cn1

InChI Key InChIKey=PDOQBOJDRPLBQU-QMMMGPOBSA-N

Data  9 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50335201   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335201(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50:  58nMAssay Description:Inhibition of JAK2 using 5 mM of ATPMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335201(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50:  1.36E+3nMAssay Description:Inhibition of JAK3 using 5 mM of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 5A(Homo sapiens (Human))
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335201(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50:  41nMAssay Description:Inhibition of Stat5 phosphorylation in human HEL cells after 1 hr by Western blottingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335201(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50:  80nMAssay Description:Inhibition of Stat3 phosphorylation in human HEL cells after 1 hr by Western blottingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335201(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50:  0.400nMAssay Description:Competitive inhibition of JAK2 (unknown origin) in the presence of ATPMore data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335201(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50:  23nMAssay Description:Inhibition of Stat3 phosphorylation in human SET2 cells after 1 hr by Western blottingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335201(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50:  3nMAssay Description:Inhibition of TrkAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))TBA
LigandPNGBDBM50335201(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50:  1.30nMAssay Description:Competitive inhibition of JAK1 (unknown origin) in the presence of ATPMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSignal transducer and activator of transcription 5A(Homo sapiens (Human))
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335201(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50:  25nMAssay Description:Inhibition of Stat5 phosphorylation in human SET2 cells after 1 hr by Western blottingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed