BDBM50335201 5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine::CHEMBL1231124
SMILES C[C@H](Nc1ncc(Cl)c(Nc2cc(C)n[nH]2)n1)c1ncc(F)cn1
InChI Key InChIKey=PDOQBOJDRPLBQU-QMMMGPOBSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 50335201
Affinity DataIC50: 58nMAssay Description:Inhibition of JAK2 using 5 mM of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 1.36E+3nMAssay Description:Inhibition of JAK3 using 5 mM of ATPMore data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 5A(Homo sapiens (Human))
Astrazeneca R&D
Curated by ChEMBL
Astrazeneca R&D
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of Stat5 phosphorylation in human HEL cells after 1 hr by Western blottingMore data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
Astrazeneca R&D
Curated by ChEMBL
Astrazeneca R&D
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibition of Stat3 phosphorylation in human HEL cells after 1 hr by Western blottingMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Competitive inhibition of JAK2 (unknown origin) in the presence of ATPMore data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
Astrazeneca R&D
Curated by ChEMBL
Astrazeneca R&D
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibition of Stat3 phosphorylation in human SET2 cells after 1 hr by Western blottingMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Astrazeneca R&D
Curated by ChEMBL
Astrazeneca R&D
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Competitive inhibition of JAK1 (unknown origin) in the presence of ATPMore data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 5A(Homo sapiens (Human))
Astrazeneca R&D
Curated by ChEMBL
Astrazeneca R&D
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of Stat5 phosphorylation in human SET2 cells after 1 hr by Western blottingMore data for this Ligand-Target Pair