BDBM50335462 1-(4-(5-benzylbenzofuran-2-yl)-3-fluorobenzyl)azetidine-3-carboxylic acid::CHEMBL1651717

SMILES OC(=O)C1CN(Cc2ccc(-c3cc4cc(Cc5ccccc5)ccc4o3)c(F)c2)C1

InChI Key InChIKey=SQBGXZIKFRKWJQ-UHFFFAOYSA-N

Data  1 IC50  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50335462   

TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50335462(1-(4-(5-benzylbenzofuran-2-yl)-3-fluorobenzyl)azet...)
Affinity DataEC50:  160nMAssay Description:Agonist activity at human S1P1R expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50335462(1-(4-(5-benzylbenzofuran-2-yl)-3-fluorobenzyl)azet...)
Affinity DataEC50:  2.70E+4nMAssay Description:Agonist activity at human S1P3R expressed in CHO cells by Ca(2+) mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50335462(1-(4-(5-benzylbenzofuran-2-yl)-3-fluorobenzyl)azet...)
Affinity DataEC50:  57nMAssay Description:Agonist activity at human S1P1 receptor expressed in human U2OS cells co-expressing eGFP assessed as receptor internalization after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50335462(1-(4-(5-benzylbenzofuran-2-yl)-3-fluorobenzyl)azet...)
Affinity DataEC50:  57nMAssay Description:Induction of human GFP-tagged chimeric S1P1R internalization in human U2Os cells by fluorescence microscopyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50335462(1-(4-(5-benzylbenzofuran-2-yl)-3-fluorobenzyl)azet...)
Affinity DataEC50:  1.73E+3nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells co-expressing Gq/i5 G-protein assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50335462(1-(4-(5-benzylbenzofuran-2-yl)-3-fluorobenzyl)azet...)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of human ERG by patch-clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed