BDBM50336043 2-(4-(2-(4-(4-cyano-1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenoxy)ethyl)piperidin-1-yl)-N,N-dimethylacetamide::CHEMBL1669276::US9115126, Reference imidazopyridine derivative EP 09150709.5 - Example 14d

SMILES CN(C)C(=O)CN1CCC(CCOc2ccc(cc2C(F)(F)F)-c2cc3n(C)cnc3c(n2)C#N)CC1

InChI Key InChIKey=QZSRDKWUUVVBAE-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50336043   

TargetCathepsin S(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50336043(2-(4-(2-(4-(4-cyano-1-methyl-1H-imidazo[4,5-c]pyri...)
Affinity DataIC50:  8.30nMAssay Description:The inhibitory activity of the compounds of the invention was demonstrated in vitro by measuring the inhibition of recombinant human Cathepsin S as f...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetCathepsin S(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50336043(2-(4-(2-(4-(4-cyano-1-methyl-1H-imidazo[4,5-c]pyri...)
Affinity DataIC50:  22nMAssay Description:Inhibition of cathepsin S in human JY cells assessed as accumulation of lip10 by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin L2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50336043(2-(4-(2-(4-(4-cyano-1-methyl-1H-imidazo[4,5-c]pyri...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human cathepsin VMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50336043(2-(4-(2-(4-(4-cyano-1-methyl-1H-imidazo[4,5-c]pyri...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin S(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50336043(2-(4-(2-(4-(4-cyano-1-methyl-1H-imidazo[4,5-c]pyri...)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin K(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50336043(2-(4-(2-(4-(4-cyano-1-methyl-1H-imidazo[4,5-c]pyri...)
Affinity DataIC50:  407nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProcathepsin L(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50336043(2-(4-(2-(4-(4-cyano-1-methyl-1H-imidazo[4,5-c]pyri...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed