BDBM50337127 2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one::CHEMBL1673039::US9266890, IV-1
SMILES COc1cc(ccc1Nc1ncc2N(C)C(=O)c3ccccc3N(C)c2n1)N1CCN(C)CC1
InChI Key InChIKey=DDTPGANIPBKTNU-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 50337127
Affinity DataKd: 19nMAssay Description:In vitro Erk5 binding assay: Ambit Kd values in nanomolar. Kd values generated by Ambit binding assay over a concentration range of the compound.More data for this Ligand-Target Pair
Affinity DataKd: 1.20nMAssay Description:Binding affinity to DCAMKL1 by immobilized ligand displacement assayMore data for this Ligand-Target Pair
Affinity DataKd: 10nMAssay Description:Binding affinity to DCAMKL2 by immobilized ligand displacement assayMore data for this Ligand-Target Pair
Affinity DataKd: 450nMAssay Description:Binding affinity to GAK by immobilized ligand displacement assayMore data for this Ligand-Target Pair
Affinity DataKd: 29nMAssay Description:Binding affinity to TNK1 by immobilized ligand displacement assayMore data for this Ligand-Target Pair
Affinity DataIC50: 888nMAssay Description:Inhibition of BRD4 bromodomain 1 (unknown origin) by AlphaScreen displacement assayMore data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged DCLK1 (G351 to H689 residues) expressed in Escherichia coli BL21 DE3 using 5-FAM-KKLRRTLSVA-CO...More data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of recombinant human GST-tagged LRRK2 catalytic domain (970 to 2527 residues) expressed in baculovirus expression system using LRRKtide as...More data for this Ligand-Target Pair
Affinity DataIC50: 959nMAssay Description:Inhibition of tracer 236 binding to recombinant human GST-tagged TNK2 catalytic domain (110 to 476 residues) expressed in baculovirus expression syst...More data for this Ligand-Target Pair
Affinity DataIC50: 87nMAssay Description:Inhibition of ERK5 in human HeLa cells assessed as reduction in EGF-induced ERK5 autophosphorylation pretreated for 1 hr followed by EGF stimulation ...More data for this Ligand-Target Pair
Affinity DataKd: 440nMAssay Description:Binding affinity to TNK2 by immobilized ligand displacement assayMore data for this Ligand-Target Pair