BDBM50337745 CHEMBL1683446::N-((2S,4S)-1-(4-(2,4-dichlorophenethyl)piperazin-1-ylsulfonyl)-4-(5-fluoropyrimidin-2-yl)-2-methylpentan-2-yl)-N-hydroxyformamide::US10322143, Compound 5

SMILES C[C@@H](C[C@@](C)(CS(=O)(=O)N1CCN(CCc2ccc(Cl)cc2Cl)CC1)N(O)C=O)c1ncc(F)cn1

InChI Key InChIKey=KPFZRWSNHNPUHB-SBUREZEXSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50337745   

TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Human)
Universitetet I Oslo

US Patent
LigandPNGBDBM50337745(CHEMBL1683446 | N-((2S,4S)-1-(4-(2,4-dichlorophene...)
Affinity DataIC50:  3.80nMAssay Description:Protein concentrations were measured using the Micro BCA Protein Assay Kit (Pierce/Thermo Scientific, IL). Sample buffer was mixed with 5-25 μg ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Human)
Universitetet I Oslo

US Patent
LigandPNGBDBM50337745(CHEMBL1683446 | N-((2S,4S)-1-(4-(2,4-dichlorophene...)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage by measuring increase in fluorescence after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed