BDBM50337838 1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methylmethanamine::CHEMBL1683870::US10562878, Compound 75

SMILES CNCC1(CCCCC1)c1ccc(Cl)c(Cl)c1

InChI Key InChIKey=NDMODESSMWGHBK-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50337838   

TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337838(1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methylmetha...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human recombinant dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent noradrenaline transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337838(1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methylmetha...)
Affinity DataIC50:  85nMAssay Description:Inhibition of human recombinant Norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent serotonin transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337838(1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methylmetha...)
Affinity DataIC50:  169nMAssay Description:Inhibition of human recombinant serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent noradrenaline transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337838(1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methylmetha...)
Affinity DataIC50:  85nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human human recombinant NET expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent serotonin transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337838(1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methylmetha...)
Affinity DataIC50:  169nMAssay Description:Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent dopamine transporter(Rat)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337838(1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methylmetha...)
Affinity DataIC50:  58nMAssay Description:Quantification of dopamine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat striatum. The uptake of...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetSodium-dependent serotonin transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337838(1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methylmetha...)
Affinity DataIC50:  169nMAssay Description:Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetNeuroepithelial cell-transforming gene 1 protein(Human)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337838(1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methylmetha...)
Affinity DataIC50:  85nMAssay Description:Inhibition of human norepinephrine reuptake transporter was assayed using the recombinant human norepinephrine transporter expressed in either HEK293...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337838(1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methylmetha...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetSodium-dependent serotonin transporter(Rat)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337838(1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methylmetha...)
Affinity DataIC50:  110nMAssay Description:Quantification of 5-HT uptake was performed using synaptosomes isolated in a 0.32M sucrose buffer from a male Wistar rat cortex. The uptake of radiol...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetNeuroepithelial cell-transforming 1(Rat)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337838(1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methylmetha...)
Affinity DataIC50:  20nMAssay Description:Quantification of norepinephrine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat hypothalamus. The...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337838(1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methylmetha...)
Affinity DataIC50:  21nMAssay Description:Inhibition of [3H]dopamine reuptake at human human recombinant DAT expressed in COS-7 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed