BDBM50340013 6,8-dichloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-trifluoropropyl)-4H-1,2,4-triazol-3-yl)methyl)-2H-benzo[b][1,4]oxazin-3(4H)-one::CHEMBL1762505

SMILES FC(F)(F)CCn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2c(Cl)cc(Cl)cc12

InChI Key InChIKey=SQEQQCICFNBUOP-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50340013   

TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340013(6,8-dichloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-tr...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340013(6,8-dichloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-tr...)
Affinity DataIC50:  6.29E+3nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/myo-inositol cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340013(6,8-dichloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-tr...)
Affinity DataIC50:  9.20E+3nMAssay Description:Inhibition of SGLT6 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillation co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340013(6,8-dichloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-tr...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340013(6,8-dichloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-tr...)
Affinity DataIC50:  20nMAssay Description:Displacement of [3H]dapagliflozin from human SGLT2 expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340013(6,8-dichloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-tr...)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of human SGLT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340013(6,8-dichloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-tr...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed