BDBM50340127 CHEMBL1760040::N4-(isoquinolin-3-yl)-N2-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine

SMILES COc1cc(Nc2nccc(Nc3cc4ccccc4cn3)n2)cc(OC)c1OC

InChI Key InChIKey=CWYKWONCBMPHGJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50340127   

TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340127(CHEMBL1760040 | N4-(isoquinolin-3-yl)-N2-(3,4,5-tr...)
Affinity DataIC50:  14nMAssay Description:Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340127(CHEMBL1760040 | N4-(isoquinolin-3-yl)-N2-(3,4,5-tr...)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed