BDBM50340668 CHEMBL1762207::methyl 2-(5,7-difluoro-2,2-dimethyl-6-(3-methyl-1H-indol-7-yl)-2,3-dihydroquinolin-4(1H)-ylideneaminooxy)-2-methylpropanoate

SMILES COC(=O)C(C)(C)O\N=C1/CC(C)(C)Nc2cc(F)c(c(F)c12)-c1cccc2c(C)c[nH]c12

InChI Key InChIKey=NFYJVUPADUMVIG-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50340668   

TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340668(methyl 2-(5,7-difluoro-2,2-dimethyl-6-(3-methyl-1H...)
Affinity DataKi:  1.5nMAssay Description:Displacement of radiolabeled Dexamethasone from glucocorticoid receptor expressed in baculovirusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340668(methyl 2-(5,7-difluoro-2,2-dimethyl-6-(3-methyl-1H...)
Affinity DataIC50: 22nMAssay Description:Transrepression activity at glucocorticoid receptor in human HepG2 cells assessed as inhibition of TNFalpha/IL1beta-stimulated NFkappaB-dependent E-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed