BDBM50342176 CHEMBL1766177::rac-N-{4'-[1-Hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-4-yl}acetamide

SMILES CC(=O)Nc1ccc(-c2ccc(C(O)(c3cnc[nH]3)C(C)C)cc2)cc1

InChI Key InChIKey=MDJDLHSQYRTGNB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50342176   

TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rat)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342176BDBM50342176(rac-N-{4'-[1-Hydroxy-1-(1H-imidazol-4-yl)-2-methyl...)
Affinity DataIC50: 24nMAssay Description:Inhibition of 17,20 lyase activity in Sprague-Dawley rat testicular microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342176BDBM50342176(rac-N-{4'-[1-Hydroxy-1-(1H-imidazol-4-yl)-2-methyl...)
Affinity DataIC50: 120nMAssay Description:Inhibition of human 17,20 lyase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342176BDBM50342176(rac-N-{4'-[1-Hydroxy-1-(1H-imidazol-4-yl)-2-methyl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human CYP3A4 after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed