BDBM50342179 CHEMBL1766180::rac-N-{4'-[1-Hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-3-yl}-N'-methylurea

SMILES CNC(=O)Nc1cccc(-c2ccc(C(O)(c3cnc[nH]3)C(C)C)cc2)c1

InChI Key InChIKey=FDFWKYDHOYTJRK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50342179   

TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342179BDBM50342179(rac-N-{4'-[1-Hydroxy-1-(1H-imidazol-4-yl)-2-methyl...)
Affinity DataIC50: 21nMAssay Description:Inhibition of human 17,20 lyase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rat)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342179BDBM50342179(rac-N-{4'-[1-Hydroxy-1-(1H-imidazol-4-yl)-2-methyl...)
Affinity DataIC50: 24nMAssay Description:Inhibition of 17,20 lyase activity in Sprague-Dawley rat testicular microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342179BDBM50342179(rac-N-{4'-[1-Hydroxy-1-(1H-imidazol-4-yl)-2-methyl...)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of human CYP3A4 after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed