BDBM50343531 2-chloro-5-(4-chloro-2-(3-(3-(trifluoromethyl)phenyl)ureido)phenoxy)-3-methylbenzenesulfonic acid::CHEMBL1774310

SMILES Cc1cc(Oc2ccc(Cl)cc2NC(=O)Nc2cccc(c2)C(F)(F)F)cc(c1Cl)S(O)(=O)=O

InChI Key InChIKey=HOXXPVIMYCPSKY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50343531   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50343531(2-chloro-5-(4-chloro-2-(3-(3-(trifluoromethyl)phen...)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of human recombinant 5-LO in cell-free system assessed as inhibition of LTB4 production after 10 mins by RP-HPLC assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin E synthase(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50343531(2-chloro-5-(4-chloro-2-(3-(3-(trifluoromethyl)phen...)
Affinity DataIC50:  400nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50343531(2-chloro-5-(4-chloro-2-(3-(3-(trifluoromethyl)phen...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of 5-LO in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production after 10 mins by RP-HPLC assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed