BDBM50346870 CHEMBL1797647

SMILES [#6]-[#16]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6])-[#7])-[#6@@H](-[#6])-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6@@H](-[#6@@H](-[#6])-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6@@H](-[#6])-[#8])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](-[#8])=O

InChI Key InChIKey=SNZBTOXJQFMTHW-BOYDWSSTSA-N

Data  6 KI  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50346870   

TargetLysine-specific histone demethylase 1A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50346870(CHEMBL1797647)
Affinity DataKi:  40nMAssay Description:Inhibition of human recombinant KDM1A expressed in Escherichia coli using H3K4me as substrate by peroxidase coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetLysine-specific histone demethylase 1A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50346870(CHEMBL1797647)
Affinity DataKi:  40nMAssay Description:Inhibition of recombinant human LSD1 expressed in Escherichia coli using methylated H3-K4 peptide as substrate by peroxidase-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetLysine-specific histone demethylase 1A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50346870(CHEMBL1797647)
Affinity DataKi:  40nMAssay Description:Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat prostatic vas deferens (alpha1A adrenoceptor)More data for this Ligand-Target Pair
In DepthDetails PubMed

TargetREST corepressor 1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50346870(CHEMBL1797647)
Affinity DataKi:  50nMAssay Description:Mean functional activity against human H3 receptorMore data for this Ligand-Target Pair
In DepthDetails PubMed

TargetLysine-specific histone demethylase 1A/REST corepressor 1 [4-485](Human)
Medical University of South Carolina

Curated by ChEMBL
LigandPNGBDBM50346870(CHEMBL1797647)
Affinity DataKi:  50nMAssay Description:Inhibition of recombinant human LSD1/CoREST complex expressed in Escherichia coli using methylated H3-K4 peptide as substrate by peroxidase-coupled a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetLysine-specific histone demethylase 1A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50346870(CHEMBL1797647)
Affinity DataKi:  50nMAssay Description:Inhibition of LSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetLysine-specific histone demethylase 1A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50346870(CHEMBL1797647)
Affinity DataKd:  140nMAssay Description:Binding affinity to human KDM1A (514 to 2499 residues) expressed in Escherichia coli Rosetta 2 assessed as dissociation constant by SPR Biosensor ass...More data for this Ligand-Target Pair
In DepthDetails PubMed