BDBM50347389 CHEMBL1801932

SMILES CC(C)c1cnn2c(NCc3ccccc3)cc(NCCCCCCN)nc12

InChI Key InChIKey=DNYBIOICMDTDAP-UHFFFAOYSA-N

Data  23 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 50347389   

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Imperial College

Curated by ChEMBL

LigandBDBM50347389(CHEMBL1801932)Copy SMILESCopy InChI

Affinity DataIC50:  21nMAssay Description:Inhibition of CDK7/cyclinH/MAT1 assessed as amount of ATP released by luciferase activity based PKLight assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
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TargetCyclin-dependent kinase 9(Human)
Lebanese American University

Curated by ChEMBL

LigandBDBM50347389(CHEMBL1801932)Copy SMILESCopy InChI

Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
University of Tours

Curated by ChEMBL

LigandBDBM50347389(CHEMBL1801932)Copy SMILESCopy InChI

Affinity DataIC50:  4.47E+4nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) using RPPTLSPIPHIPR peptide as substrate in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
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TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
University of Tours

Curated by ChEMBL

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Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of CDK1/Cyclin B (unknown origin) expressed in baculoviral infected insect Sf9 cells using histone H1 as substrate in presence of [gamma-3...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetCyclin-dependent kinase 5(Human)
Palack£

Curated by ChEMBL

LigandBDBM50347389(CHEMBL1801932)Copy SMILESCopy InChI

Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of CDK5 (unknown origin) using histone H1 as substrate in presence of [gamma33P]-ATPMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
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TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Palack£

Curated by ChEMBL

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Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin) expressed in sf9 cells using histone H1 as substrate in presence of [gamma33P]-ATPMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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TargetCyclin-dependent kinase 9(Human)
Lebanese American University

Curated by ChEMBL

LigandBDBM50347389(CHEMBL1801932)Copy SMILESCopy InChI

Affinity DataIC50:  2.18E+3nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetCyclin-dependent kinase 7(Human)
Palack£

Curated by ChEMBL

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Affinity DataIC50:  134nMAssay Description:Inhibition of CDK7 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
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In DepthDetails ArticlePubMedPDB3D Structure (crystal)
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TargetCyclin-dependent kinase 4(Human)
Palack£

Curated by ChEMBL

LigandBDBM50347389(CHEMBL1801932)Copy SMILESCopy InChI

Affinity DataIC50:  4.47E+4nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
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TargetCyclin-dependent kinase 1(Human)
Palack£

Curated by ChEMBL

LigandBDBM50347389(CHEMBL1801932)Copy SMILESCopy InChI

Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
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In DepthDetails ArticlePubMed
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TargetCyclin-dependent kinase 7(Human)
Palack£

Curated by ChEMBL

LigandBDBM50347389(CHEMBL1801932)Copy SMILESCopy InChI

Affinity DataIC50:  21nMAssay Description:Competitive reversible inhibition of CDK7 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankGoogleScholar

Ligand InfoPurchaseCHEMBLMCE
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In DepthDetails ArticlePubMedPDB3D Structure (crystal)
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TargetCyclin-dependent kinase 4(Human)
Palack£

Curated by ChEMBL

LigandBDBM50347389(CHEMBL1801932)Copy SMILESCopy InChI

Affinity DataIC50:  3.30E+4nMAssay Description:Competitive reversible inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
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TargetCyclin-dependent kinase 6(Human)
Eli Lilly

Curated by ChEMBL

LigandBDBM50347389(CHEMBL1801932)Copy SMILESCopy InChI

Affinity DataIC50:  4.70E+4nMAssay Description:Competitive reversible inhibition of CDK6 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
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TargetCyclin-dependent kinase 8(Human)
Eli Lilly

Curated by ChEMBL

LigandBDBM50347389(CHEMBL1801932)Copy SMILESCopy InChI

Affinity DataIC50:  4.20E+3nMAssay Description:Competitive reversible inhibition of CDK8 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
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TargetCyclin-dependent kinase 2(Human)
Eli Lilly

Curated by ChEMBL

LigandBDBM50347389(CHEMBL1801932)Copy SMILESCopy InChI

Affinity DataIC50:  900nMAssay Description:Competitive reversible inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
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TargetCyclin-dependent kinase 5(Human)
Palack£

Curated by ChEMBL

LigandBDBM50347389(CHEMBL1801932)Copy SMILESCopy InChI

Affinity DataIC50:  3.00E+3nMAssay Description:Competitive reversible inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
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In DepthDetails ArticlePubMed
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TargetCyclin-dependent kinase 7(Human)
Palack£

Curated by ChEMBL

LigandBDBM50347389(CHEMBL1801932)Copy SMILESCopy InChI

Affinity DataIC50:  21nMAssay Description:Inhibition of CDK7 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPurchaseCHEMBLMCE
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In DepthDetails ArticlePubMedPDB3D Structure (crystal)
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TargetCyclin-dependent kinase 1(Human)
Palack£

Curated by ChEMBL

LigandBDBM50347389(CHEMBL1801932)Copy SMILESCopy InChI

Affinity DataIC50:  8.10E+3nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
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In DepthDetails ArticlePubMed
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TargetCyclin-dependent kinase 2(Human)
Eli Lilly

Curated by ChEMBL

LigandBDBM50347389(CHEMBL1801932)Copy SMILESCopy InChI

Affinity DataIC50:  880nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
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TargetCyclin-dependent kinase 4(Human)
Palack£

Curated by ChEMBL

LigandBDBM50347389(CHEMBL1801932)Copy SMILESCopy InChI

Affinity DataIC50:  3.30E+4nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
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In DepthDetails ArticlePubMed
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TargetCyclin-dependent kinase 5(Human)
Palack£

Curated by ChEMBL

LigandBDBM50347389(CHEMBL1801932)Copy SMILESCopy InChI

Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPurchaseCHEMBLMCE
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In DepthDetails ArticlePubMed
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TargetCyclin-dependent kinase 6(Human)
Eli Lilly

Curated by ChEMBL

LigandBDBM50347389(CHEMBL1801932)Copy SMILESCopy InChI

Affinity DataIC50:  4.70E+4nMAssay Description:Inhibition of CDK6 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPurchaseCHEMBLMCE
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In DepthDetails ArticlePubMed
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TargetCyclin-dependent kinase 5 activator 1(Human)
University of Tours

Curated by ChEMBL

LigandBDBM50347389(CHEMBL1801932)Copy SMILESCopy InChI

Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of CDK5/p35NCK (unknown origin) using histone H1 as substrate in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
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In DepthDetails ArticlePubMed
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