BDBM50348430 CHEMBL1800963::US9492405, 44

SMILES COc1ccc(C[C@@H](C)NC[C@H](O)c2cc(O)cc(O)c2)c2ccccc12

InChI Key InChIKey=MLQLUFQBFMFXJO-UHFFFAOYSA-N

Data  4 KI  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50348430   

TargetBeta-2 adrenergic receptor(Human)
Medical University of Lublin

Curated by ChEMBL
LigandPNGBDBM50348430(CHEMBL1800963 | US9492405, 44)
Affinity DataEC50:  3.90nMAssay Description:Agonist activity at human beta2 adrenergic receptor expressed in HEK 293 cells assessed as stimulation of cAMP accumulation by protein kinase binding...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Medical University of Lublin

Curated by ChEMBL
LigandPNGBDBM50348430(CHEMBL1800963 | US9492405, 44)
Affinity DataIC50: 3.98nMT: 2°CAssay Description:To measure beta2-AR mediated inhibition of mitogenesis, HEK-beta2-AR, 1321N1 or U87MG cells were seeded in a 96-well plate at approximately 5,000 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
Medical University of Lublin

Curated by ChEMBL
LigandPNGBDBM50348430(CHEMBL1800963 | US9492405, 44)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]-(R,R')-methoxyfenoterol from human beta2 adrenergic receptor expressed in HEK cells by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Medical University of Lublin

Curated by ChEMBL
LigandPNGBDBM50348430(CHEMBL1800963 | US9492405, 44)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]-(R,R')-methoxyfenoterol from human beta2 adrenergic receptor expressed in HEK cells by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Rat)
Medical University of Lublin

Curated by ChEMBL
LigandPNGBDBM50348430(CHEMBL1800963 | US9492405, 44)
Affinity DataEC50:  16nMAssay Description:Agonist activity beta2-adrenergic receptor in rat ventricular myocytes assessed as cell contraction following electrical stimulation by optical edge ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Medical University of Lublin

Curated by ChEMBL
LigandPNGBDBM50348430(CHEMBL1800963 | US9492405, 44)
Affinity DataKi:  280nMAssay Description:Displacement of [3H]CGP-12177 from human beta2-adrenergic receptor expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Rat)
Medical University of Lublin

Curated by ChEMBL
LigandPNGBDBM50348430(CHEMBL1800963 | US9492405, 44)
Affinity DataKi:  1.61E+5nMAssay Description:Displacement of [3H]CGP-12177 from beta1-adrenergic receptor in Sprague-Dawley rat cortical membrane after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed