BDBM50352320 CHEMBL1822656

SMILES Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4C[C@H](O)[C@H](C4)Oc4ccccc4F)cc3)nn3cccc23)n[nH]1

InChI Key InChIKey=HIXRSEFUZBICPP-UPVQGACJSA-N

Data  1 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50352320   

TargetAurora kinase B(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50352320(CHEMBL1822656)
Affinity DataKd:  9nMAssay Description:Binding affinity to Aurora B kinase catalytic domain by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase A(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50352320(CHEMBL1822656)
Affinity DataKd:  10nMAssay Description:Binding affinity to Aurora A kinase catalytic domain by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase B(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50352320(CHEMBL1822656)
Affinity DataIC50:  28nMAssay Description:Inhibition of Aurora B kinase assessed as reduction in histone H3 phosphorylation in human HCT116 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed