BDBM50353016 CHEMBL1821978

SMILES NC1CCc2cccc(c2CC1=O)-c1ccccc1

InChI Key InChIKey=OCPQVXLDVBEGMQ-UHFFFAOYSA-N

Data  7 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50353016   

TargetAminopeptidase N(Pig)
University of Upper Alsace

Curated by ChEMBL
LigandPNGBDBM50353016(CHEMBL1821978)
Affinity DataKi:  7nMAssay Description:Inhibition of porcine kidney APN assessed as decrease in p-nitroanilide release using L-leucine-p-nitroanilide as substrate by spectrophotometric ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2016
Entry Details Article
PubMed
TargetAminopeptidase N(Pig)
University of Upper Alsace

Curated by ChEMBL
LigandPNGBDBM50353016(CHEMBL1821978)
Affinity DataKi:  7nMAssay Description:Inhibition of porcine kidney APN using L-leucine-p-nitroanilide as substrate after 30 mins by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetAminopeptidase N(Pig)
University of Upper Alsace

Curated by ChEMBL
LigandPNGBDBM50353016(CHEMBL1821978)
Affinity DataKi:  7nMAssay Description:Inhibition of pig APN using L-leucine-p-nitroanilide as substrate measured every 10 mins for 2 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAminopeptidase N(Mouse)
University of Upper Alsace

Curated by ChEMBL
LigandPNGBDBM50353016(CHEMBL1821978)
Affinity DataKi:  10nMAssay Description:Inhibition of mouse APN using L-leucine-p-nitroanilide as substrate measured every 10 mins for 2 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAminopeptidase N(Human)
University of Upper Alsace

Curated by ChEMBL
LigandPNGBDBM50353016(CHEMBL1821978)
Affinity DataKi:  11nMAssay Description:Inhibition of human APN using L-leucine-p-nitroanilide as substrate measured every 10 mins for 2 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetInterleukin-1 receptor antagonist protein(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50353016(CHEMBL1821978)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of human recombinant IRAP expressed in baculovirus infected Sf9 cells using L-AMC as substrate incubated for 5 to 10 mins by Michaelis-Men...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEndoplasmic reticulum aminopeptidase 2(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50353016(CHEMBL1821978)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of human recombinant ERAP2 expressed in baculovirus infected sf9 cells using R-AMC as substrate incubated for 5 to 10 mins by Michaelis-Me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetBacterial leucyl aminopeptidase(Vibrio proteolyticus)
University of Upper Alsace

Curated by ChEMBL
LigandPNGBDBM50353016(CHEMBL1821978)
Affinity DataKi:  2.80E+4nMAssay Description:Inhibition of Aeromonas proteolytica aminopeptidase using L-leucine-p-nitroanilide as substrate after 30 mins by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetEndoplasmic reticulum aminopeptidase 1(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50353016(CHEMBL1821978)
Affinity DataIC50: 6.30E+4nMAssay Description:Inhibition of human recombinant ERAP1 expressed in baculovirus infected sf9 cells using L-AMC as substrate incubated for 5 to 10 mins by Michaelis-Me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCytosol aminopeptidase(Bovine)
University of Upper Alsace

Curated by ChEMBL
LigandPNGBDBM50353016(CHEMBL1821978)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of bovine kidney cytosolic leucine aminopeptidase using L-leucine-p-nitroanilide as substrate after 30 mins by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed