BDBM50353432 CHEMBL1829876::US10196373, Compound 45O

SMILES CN(CC(=O)N(Cc1ccc(cc1)C1CCCCC1)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F

InChI Key InChIKey=WNVSFFVDMUSXSX-UHFFFAOYSA-N

Data  2 KI  8 IC50  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 50353432   

TargetSignal transducer and activator of transcription 3(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50353432(CHEMBL1829876 | US10196373, Compound 45O)
Affinity DataKd:  500nMAssay Description:Binding affinity to full length STAT3 (unknown origin) by Surface plasmon resonanceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50353432(CHEMBL1829876 | US10196373, Compound 45O)
Affinity DataKd:  504nMAssay Description:Binding affinity to STAT3 (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50353432(CHEMBL1829876 | US10196373, Compound 45O)
Affinity DataKd:  504nMAssay Description:Binding affinity to STAT3 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50353432(CHEMBL1829876 | US10196373, Compound 45O)
Affinity DataKd:  4.57E+3nMAssay Description:Binding affinity to His-tagged STAT3 (127 to 722 residues) (unknown origin) incubated for 30 mins by MST assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50353432(CHEMBL1829876 | US10196373, Compound 45O)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of C-terminal 6His-tagged recombinant human STAT3 (127 to 711 residues) DNA-binding activity transfected in v-Src transformed mouse NIH3T3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50353432(CHEMBL1829876 | US10196373, Compound 45O)
Affinity DataIC50: 5.30E+3nMAssay Description:Displacement of 5-carboxyfluorescein GpYLPQTV-NH2 probe from C-terminal 6His-tagged recombinant human STAT3 (127 to 711 residues) SH2 domain extracte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50353432(CHEMBL1829876 | US10196373, Compound 45O)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of C-terminal 6His-tagged recombinant human STAT3 (127 to 711 residues) DNA-binding activity transfected in v-Src transformed mouse NIH3T3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Mouse)
University of Hawaii Cancer Center

Curated by ChEMBL
LigandPNGBDBM50353432(CHEMBL1829876 | US10196373, Compound 45O)
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of STAT3 DNA binding activity in mouse NIH/3T3 nuclear extract preincubated for 30 mins followed by [32P]hSIE addition measured after 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50353432(CHEMBL1829876 | US10196373, Compound 45O)
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of STAT3 (unknown origin) binding to DNA by EMSA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50353432(CHEMBL1829876 | US10196373, Compound 45O)
Affinity DataIC50: 6.80E+3nMAssay Description:Displacement of 5-carboxyfluorescein GpYLPQTV-NH2 probe from C-terminal 6His-tagged recombinant human STAT3 (127 to 711 residues) SH2 domain extracte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50353432(CHEMBL1829876 | US10196373, Compound 45O)
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of STAT3 (unknown origin) DNA binding activity by EMSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50353432(CHEMBL1829876 | US10196373, Compound 45O)
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of recombinant STAT3 (unknown origin) expressed in baculovirus in Sf9 insect cells assessed as reduction in DNA binding activity with NIH3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50353432(CHEMBL1829876 | US10196373, Compound 45O)
Affinity DataIC50: 6.80E+3nMAssay Description:ChIP assay was performed using EZ ChIP Kit (Millipore, Billerica, Mass., USA) as per manufacturer's instruction. Briefly, after crosslinking with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details
US Patent

TargetSignal transducer and activator of transcription 3(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50353432(CHEMBL1829876 | US10196373, Compound 45O)
Affinity DataIC50: 6.80E+3nMAssay Description:Binding affinity to Stat3 (unknown origin) using hSIE as probe preincubated for 30 mins followed by hSIE addition by electrophoretic mobility shift a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50353432(CHEMBL1829876 | US10196373, Compound 45O)
Affinity DataIC50: 1.06E+4nMAssay Description:Inhibition of recombinant wild type tyrosine phosphorylated C-terminal 6His tagged human STAT3 C426A mutant (127 to 711 residues) DNA-binding activit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50353432(CHEMBL1829876 | US10196373, Compound 45O)
Affinity DataIC50: 1.12E+4nMAssay Description:Inhibition of recombinant wild type tyrosine phosphorylated C-terminal 6His tagged human STAT3 C328A mutant (127 to 711 residues) DNA-binding activit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50353432(CHEMBL1829876 | US10196373, Compound 45O)
Affinity DataKi:  1.28E+4nMAssay Description:Inhibition of STAT3 using fluorescent probe 5-carboxyfluorescein-GpYLPQTV-NH2 after 15 mins by fluorescence polarisation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50353432(CHEMBL1829876 | US10196373, Compound 45O)
Affinity DataKi:  1.30E+4nMAssay Description:ChIP assay was performed using EZ ChIP Kit (Millipore, Billerica, Mass., USA) as per manufacturer's instruction. Briefly, after crosslinking with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details
US Patent

TargetSignal transducer and activator of transcription 3(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50353432(CHEMBL1829876 | US10196373, Compound 45O)
Affinity DataIC50: 1.36E+4nMAssay Description:Inhibition of recombinant wild type tyrosine phosphorylated C-terminal 6His tagged human STAT3 (127 to 711 residues) DNA-binding activity transfected...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50353432(CHEMBL1829876 | US10196373, Compound 45O)
Affinity DataIC50: 1.67E+4nMAssay Description:Inhibition of C-terminal 6His-tagged recombinant human STAT3 (127 to 711 residues) DNA-binding activity transfected in v-Src transformed mouse NIH3T3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Mouse)
University of Hawaii Cancer Center

Curated by ChEMBL
LigandPNGBDBM50353432(CHEMBL1829876 | US10196373, Compound 45O)
Affinity DataIC50: 1.97E+4nMAssay Description:Inhibition of STAT3 in mouse NIH3T3/vSrc nuclear extract assessed as disruption of the Stat3-DNA complex pre-incubated for 30 mins by EMSA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50353432(CHEMBL1829876 | US10196373, Compound 45O)
Affinity DataIC50: 2.01E+4nMAssay Description:Inhibition of recombinant wild type tyrosine phosphorylated C-terminal 6His tagged human STAT3 C468A mutant (127 to 711 residues) DNA-binding activit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50353432(CHEMBL1829876 | US10196373, Compound 45O)
Affinity DataIC50: 2.23E+4nMAssay Description:Displacement of 5-carboxyfluorescein GpYLPQTV-NH2 probe from C-terminal 6His-tagged recombinant human STAT3 (127 to 711 residues) SH2 domain extracte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50353432(CHEMBL1829876 | US10196373, Compound 45O)
Affinity DataIC50: 2.27E+4nMAssay Description:Inhibition of recombinant wild type tyrosine phosphorylated C-terminal 6His tagged human STAT3 C542S mutant (127 to 711 residues) DNA-binding activit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50353432(CHEMBL1829876 | US10196373, Compound 45O)
Affinity DataIC50: 2.56E+4nMAssay Description:Competitive binding affinity to Stat3 SH2 domain (unknown origin) using 5-FAM-GpYLPQTV-NH2 as probe assessed as phosphopetide complex formation after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed