BindingDB BDBM50357870 CHEMBL1916130

BDBM50357870 CHEMBL1916130

SMILES COc1cc(cc2c1nc(C)c1c(C)nc(-c3ccncc3C)n21)C(F)(F)F

InChI Key InChIKey=RFLZKIMBCYCKIA-UHFFFAOYSA-N

Data 11 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50357870

cGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Pfizer

Curated by ChEMBL

BDBM50357870(CHEMBL1916130)

IC50: >500nMAssay Description:Inhibition of recombinant human PDE5A using [3H]cGMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Pfizer

Curated by ChEMBL

BDBM50357870(CHEMBL1916130)

IC50: >500nMAssay Description:Inhibition of recombinant human PDE11A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Pfizer

Curated by ChEMBL

BDBM50357870(CHEMBL1916130)

IC50: 0.0900nMAssay Description:Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Pfizer

Curated by ChEMBL

BDBM50357870(CHEMBL1916130)

IC50: >500nMAssay Description:Inhibition of recombinant human PDE3A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Pfizer

Curated by ChEMBL

BDBM50357870(CHEMBL1916130)

IC50: >500nMAssay Description:Inhibition of recombinant human PDE4A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Pfizer

Curated by ChEMBL

BDBM50357870(CHEMBL1916130)

IC50: >500nMAssay Description:Inhibition of recombinant human PDE9A using [3H]cGMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Human)
Pfizer

Curated by ChEMBL

BDBM50357870(CHEMBL1916130)

IC50: >500nMAssay Description:Inhibition of recombinant human PDE1B using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Pfizer

Curated by ChEMBL

BDBM50357870(CHEMBL1916130)

IC50: 112nMAssay Description:Inhibition of recombinant human PDE2A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Pfizer

Curated by ChEMBL

BDBM50357870(CHEMBL1916130)

IC50: >500nMAssay Description:Inhibition of recombinant human PDE7A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Human)
Pfizer

Curated by ChEMBL

BDBM50357870(CHEMBL1916130)

IC50: >500nMAssay Description:Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Bovine)
Pfizer

Curated by ChEMBL

BDBM50357870(CHEMBL1916130)

IC50: >500nMAssay Description:Inhibition of recombinant bovine PDE6A using [3H]cGMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Filter my 11 hits

Targets 11▿
- High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A 1
- Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A 1
- cGMP-specific 3',5'-cyclic phosphodiesterase 1
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 1
- cAMP-specific 3',5'-cyclic phosphodiesterase 4A 1
- cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A 1
- High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A 1
- cGMP-dependent 3',5'-cyclic phosphodiesterase 1
- Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha 1
- cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 1
- High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A 1
Publications 1▿
- J Med Chem 54: 7621-38 (2011) 11
Institutions 1▿
- Pfizer 11
Affinity: 0.090 to 5.0E+2 nM▿
- IC50 11
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 0