BDBM50359200 CHEMBL1923295

SMILES CN1CC(N)=NC(C)(C1=O)c1cccc(NC(=O)c2ccc(cn2)C(F)(F)F)c1

InChI Key InChIKey=SLPXAQFTHUFTML-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50359200   

TargetBeta-secretase 1(Human)
Research Informatics & Integrative Genomics

Curated by ChEMBL
LigandPNGBDBM50359200(CHEMBL1923295)
Affinity DataIC50:  1.38E+3nMAssay Description:Inhibition of human recombinant BACE1 using fluorescent Mca-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys(Dnp)-OH peptide as substrate after 1 hr by spectr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-secretase 1(Human)
Research Informatics & Integrative Genomics

Curated by ChEMBL
LigandPNGBDBM50359200(CHEMBL1923295)
Affinity DataIC50:  79nMAssay Description:Inhibition of human BACE1-mediated amyloid beta TOT secretion in human SKNBE2 cells expressing human APP695 after 18 hrs by sandwich alphalisa assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-secretase 1(Human)
Research Informatics & Integrative Genomics

Curated by ChEMBL
LigandPNGBDBM50359200(CHEMBL1923295)
Affinity DataIC50:  68nMAssay Description:Inhibition of human BACE1-mediated amyloid beta 42 secretion in human SKNBE2 cells expressing human APP695 after 18 hrs by sandwich alphalisa assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed