BDBM50359392 CHEMBL1929424::US8999994, 3

SMILES CN(CC#C)Cc1cc2cc(OCCCN3CCN(Cc4ccccc4)CC3)ccc2n1C

InChI Key InChIKey=SLRSNCWUOFPURJ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50359392   

TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Consejo Superior De Investigaciones Cientificas

US Patent
LigandPNGBDBM50359392(CHEMBL1929424 | US8999994, 3)
Affinity DataIC50: >1.00E+5nMpH: 8.0Assay Description:The inhibitory activity of the enzyme acetylcholinesterase (AChE) was evaluated by the Ellman method (Biochem. Pharmacol. 1961, 7, 88) using an elect...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Consejo Superior De Investigaciones Cientificas

US Patent
LigandPNGBDBM50359392(CHEMBL1929424 | US8999994, 3)
Affinity DataIC50:  7.60E+3nMpH: 8.0Assay Description:The inhibitory activity of the enzyme acetylcholinesterase (AChE) was evaluated by the Ellman method (Biochem. Pharmacol. 1961, 7, 88) using an elect...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
Consejo Superior De Investigaciones Cientificas

US Patent
LigandPNGBDBM50359392(CHEMBL1929424 | US8999994, 3)
Affinity DataIC50:  3.05E+4nMpH: 7.4 T: 2°CAssay Description:The inhibitory activity of monoamine oxidases A and B was assessed by the Fowler and Tipton radiometric method (Biochem Pharmacol 1981, 30, 3329) usi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Consejo Superior De Investigaciones Cientificas

US Patent
LigandPNGBDBM50359392(CHEMBL1929424 | US8999994, 3)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Electrophorus electricus AchE using acetylthiocholine iodide as substrate preincubated for 10 mins measured after 15 mins of substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universitat Aut£Noma De Barcelona

Curated by ChEMBL
LigandPNGBDBM50359392(CHEMBL1929424 | US8999994, 3)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of rat liver mitochondrial MAO-B using [14C]-phenylethylamine after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
Consejo Superior De Investigaciones Cientificas

US Patent
LigandPNGBDBM50359392(CHEMBL1929424 | US8999994, 3)
Affinity DataIC50:  31nMAssay Description:Inhibition of rat liver mitochondrial MAO-A using [14C]-5-hydroxytryptamine after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Universitat Aut£Noma De Barcelona

Curated by ChEMBL
LigandPNGBDBM50359392(CHEMBL1929424 | US8999994, 3)
Affinity DataIC50:  7.60E+3nMAssay Description:Inhibition of equine serum BuchE using butyrylthiocholine iodide as substrate preincubated for 10 mins measured after 15 mins of substrate addition b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universitat Aut£Noma De Barcelona

Curated by ChEMBL
LigandPNGBDBM50359392(CHEMBL1929424 | US8999994, 3)
Affinity DataIC50:  1.64E+6nMpH: 7.4 T: 2°CAssay Description:The inhibitory activity of monoamine oxidases A and B was assessed by the Fowler and Tipton radiometric method (Biochem Pharmacol 1981, 30, 3329) usi...More data for this Ligand-Target Pair
In DepthDetails US Patent