BDBM50361662 CHEMBL1940612

SMILES CCN(CCCCCC=Nc1cc(O)c2ccccc2c1O)Cc1ccccc1OC

InChI Key InChIKey=JZYHWZHQIZWTRL-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50361662   

TargetCholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50361662(CHEMBL1940612)
Affinity DataIC50: 1.49E+3nMAssay Description:Inhibition of human recombinant BuChE using butyrylthiocholine iodide as substrate after 20 mins preincubation by Ellman methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50361662(CHEMBL1940612)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of recombinant BACE1 expressed in baculovirus system using panvera peptide as substrate after 60 mins by spectrofluorometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50361662(CHEMBL1940612)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of recombinant BACE1 expressed in baculovirus system using M-2420 as substrate preincubated for 1 hr before substrate addition measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50361662(CHEMBL1940612)
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate after 20 mins preincubation by Ellman methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50361662(CHEMBL1940612)
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of human recombinant AChE-induced amyloid beta (1-40) aggregation assessed as fibril formation after 24 hrs by thioflavin T-based fluorome...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed