BDBM50363251 CHEMBL1946802

SMILES COc1cc(N2CCN(C)CC2)c2CCc3cccc(Nc4nc(Nc1c2)ncc4Cl)c3

InChI Key InChIKey=PVXFLFNVDPFZIO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50363251   

TargetALK tyrosine kinase receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50363251(CHEMBL1946802)
Affinity DataIC50: 5nMAssay Description:Inhibition of baculovirus expressed GST-tagged human ALK cytoplasmic domain using PLCgamma as substrate after 15 mins by time-resolved fluorescence a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50363251(CHEMBL1946802)
Affinity DataIC50: 800nMAssay Description:Inhibition of NPM-ALK autophosphorylation in human ALCL SUP-M2 cells after 2 to 3 hrs by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed