BDBM50364377 CHEMBL1950304

SMILES CNC(=O)[C@H]1CC[C@@H](CC1)Nc1ncc2nc(Nc3c(F)cc(F)cc3F)n([C@H]3CCOC3)c2n1

InChI Key InChIKey=YEBFCGFMUQJOCV-QEJZJMRPSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50364377   

TargetMitogen-activated protein kinase 8(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50364377(CHEMBL1950304)
Affinity DataIC50:  51nMAssay Description:Inhibition of hexa-His-tagged JNK1 expressed in baculoviral system using GST-tagged c-Jun as substrate preincubated for 15 mins prior ATP addition me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50364377(CHEMBL1950304)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of p38alpha using myelin basic protein as substrate preincubated for 15 mins prior ATP addition measured after 60 mins by scintillation co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50364377(CHEMBL1950304)
Affinity DataIC50:  7nMAssay Description:Inhibition of hexa-His-tagged JNK3 expressed in baculoviral system using GST-tagged cJun as substrate preincubated for 15 mins prior ATP addition mea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50364377(CHEMBL1950304)
Affinity DataIC50:  10nMAssay Description:Inhibition of hexa-His-tagged JNK2 expressed in baculoviral system using GST-tagged cJun as substrate preincubated for 15 mins prior ATP addition mea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed