BDBM50364676 CHEMBL1951465::US8785634, 1

SMILES FC(F)(F)Oc1ccc(CN2CCC3(CC2)OC(c2ccccc32)c2cc(Cl)ccn2)cc1

InChI Key InChIKey=LFFCKQUVNSOFQR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50364676   

TargetLysosomal Pro-X carboxypeptidase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50364676(CHEMBL1951465 | US8785634, 1)
Affinity DataIC50:  0.660nMAssay Description:The potency of compounds of formula I against PrCP was determined by a fluorescence intensity kinetic assay measuring the IC50 values of PrCP inhibit...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetLysosomal Pro-X carboxypeptidase(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50364676(CHEMBL1951465 | US8785634, 1)
Affinity DataIC50:  23nMAssay Description:Inhibition of PrCP in mouse plasma assessed as angiotensin 3 cleavage by whole serum shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetLysosomal Pro-X carboxypeptidase(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50364676(CHEMBL1951465 | US8785634, 1)
Affinity DataIC50:  0.180nMAssay Description:Inhibition of mouse PrCPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetLysosomal Pro-X carboxypeptidase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50364676(CHEMBL1951465 | US8785634, 1)
Affinity DataIC50:  0.440nMAssay Description:Inhibition of human PrCPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed