BDBM50365158 CHEMBL1950010

SMILES COc1ccc2c(CC(O)=O)c([nH]c2c1)C(=O)c1cc(C)ccn1

InChI Key InChIKey=BVLDTQOJHAZUMB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50365158   

TargetProstaglandin G/H synthase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365158(CHEMBL1950010)
Affinity DataIC50: 128nMAssay Description:Inhibition of COX-2-mediated 6-keto-PGF1alpha production in IL-1beta-induced HUVEC preincubated for 20 mins prior A23187 stimulation measured after 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365158(CHEMBL1950010)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of COX-2-mediated PGE2 production in LPS-induced human whole blood after 24 hrs by RIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365158(CHEMBL1950010)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of COX-1-mediated TXB2 production in human platelets preincubated for 20 mins prior A23187 stimulation measured after 15 mins by RIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365158(CHEMBL1950010)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of COX-1-mediated TXB2 production in human whole blood after 15 mins post A23187 stimulation by RIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed