BDBM50365215 CHEMBL1956068::GSK screening, 36

SMILES COc1ccc2[nH]c3c4[nH]c5ccc(OC)cc5c4c4C(=O)NC(=O)c4c3c2c1

InChI Key InChIKey=LGTURXDQKJRHSF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50365215   

TargetRho-associated protein kinase 2(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50365215(CHEMBL1956068 | GSK screening, 36)
Affinity DataIC50: 500nMAssay Description:Inhibition of N-terminal His10-StrepII tagged human ROCK2 catalytic domain (1 to 553 residues) expressed in Sf9 insect cells by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50365215(CHEMBL1956068 | GSK screening, 36)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of recombinant cytoplasmic domain of PDGFRbeta autophosphorylation expressed in baculovirus infected Sf21 insect cells using [gamma-33P]AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50365215(CHEMBL1956068 | GSK screening, 36)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of recombinant cytoplasmic domain of PDGFRbeta expressed in baculovirus infected Sf21 insect cells assessed as tyrosine phosphorylation tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Technical University of Dortmund

LigandPNGBDBM50365215(CHEMBL1956068 | GSK screening, 36)
Affinity DataIC50: 3.00E+3nMAssay Description:IC50 determinations for TBK1 were performed with the KinEASE-STK assay from Cisbio according to the manufacturer's instructions. A biotinylated s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2015
Entry Details Article
PubMed