BDBM50365494 CHEMBL1957381

SMILES Cc1cc(ccn1)-c1ccc(cc1)-c1nc2ccncc2c(O)c1C#N

InChI Key InChIKey=LKTSKFINPOYPKI-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50365494   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50365494(CHEMBL1957381)Copy SMILESCopy InChI

Affinity DataIC50: 27nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
7/23/2012
Entry Details Article
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50365494(CHEMBL1957381)Copy SMILESCopy InChI

Affinity DataIC50: 9.90E+3nMAssay Description:Inhibition of human recombinant DHODH transmembrane domain using 2,6-dichloroindophenol sodium, L-Dihydroorotic acid, and decylubiquinone as substrat...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
7/23/2012
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL