BDBM50365498 CHEMBL1957371

SMILES Oc1c(C#N)c(nc2ccncc12)-c1ccc(cc1)-c1cn[nH]c1

InChI Key InChIKey=NMGJYUYFTZPWPH-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50365498   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50365498(CHEMBL1957371)Copy SMILESCopy InChI

Affinity DataIC50: >9.90E+3nMAssay Description:Inhibition of human recombinant DHODH transmembrane domain using 2,6-dichloroindophenol sodium, L-Dihydroorotic acid, and decylubiquinone as substrat...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50365498(CHEMBL1957371)Copy SMILESCopy InChI

Affinity DataIC50:  1.77E+3nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI
Copy reaction URL