BDBM50370297 CHEMBL4160315

SMILES [O-]S(=O)(=O)c1ccc(NC(=O)c2cc(NC(=O)Nc3cc(cc(c3)C(=O)Nc3ccc(cc3)S([O-])(=O)=O)C(=O)Nc3ccc(cc3)S([O-])(=O)=O)cc(c2)C(=O)Nc2ccc(cc2)S([O-])(=O)=O)cc1

InChI Key InChIKey=XLJCHJYKCSKQLL-UHFFFAOYSA-J

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50370297   

TargetP2X purinoceptor 3(Rat)
Gwangju Institute of Science and Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50370297(CHEMBL4160315)
Affinity DataIC50: 500nMAssay Description:Antagonist activity at P2X3 receptor in rat DRG neurons at -70 mV holding potential by whole cell patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 3(Rat)
Gwangju Institute of Science and Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50370297(CHEMBL4160315)
Affinity DataIC50: 527nMAssay Description:Antagonist activity at P2X3 receptor in Wistar rat DRG neurons assessed as inhibition of alpha/beta-meATP-induced currents preincubated for 5 mins pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 3(Human)
Gwangju Institute of Science and Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50370297(CHEMBL4160315)
Affinity DataIC50: 1.58E+3nMAssay Description:Antagonist activity at human P2X3 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced calcium influx preincubated for 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 3(Human)
Gwangju Institute of Science and Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50370297(CHEMBL4160315)
Affinity DataIC50: 1.60E+3nMAssay Description:Antagonist activity at human P2X3 receptor expressed in 1321N1 cells assessed as inhibition of ATP-induced calcium flux measured for 30 secs at 0.4 s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed