BDBM50378747 CHEMBL1204056

SMILES C[C@H]1CN(C[C@@H](C)[C@]1(O)C1CC1)C(=O)[C@H]1CN(C[C@@H]1c1ccc(F)cc1F)c1cccnn1

InChI Key InChIKey=ORHLDSXKDGTRSE-UHFFFAOYSA-N

Data  2 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50378747   Sort by

TargetMelanocortin receptor 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50378747(CHEMBL1204056)
Affinity DataEC50:  4.13E+3nMAssay Description:Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50378747(CHEMBL1204056)
Affinity DataEC50: >1.67E+4nMAssay Description:Agonist activity at human recombinant MC1 receptor expressed in HEK293 cells assessed as cAMP accumulation by enzyme fragment complementation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50378747(CHEMBL1204056)
Affinity DataEC50:  82nMAssay Description:Agonist activity at human recombinant MC4 receptor expressed in CHO cells by cAMP responsive beta lactamase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50378747(CHEMBL1204056)
Affinity DataKi: >10nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50378747(CHEMBL1204056)
Affinity DataKi:  172nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed