BDBM50380246 CHEMBL2017214

SMILES CSc1ccccc1Nc1nc(nc2c(NCC3CC3)ncnc12)N1CCNCC1

InChI Key InChIKey=HFLMLZKGLUEWBU-UHFFFAOYSA-N

Data  38 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 38 hits for monomerid = 50380246   

TargetKetohexokinase(Human)
Janssen Pharmaceutical Companies of Johnson & Johnson

Curated by ChEMBL
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50:  12nMAssay Description:Inhibition of recombinant human hepatic KHKCMore data for this Ligand-Target Pair
TargetKetohexokinase(Human)
Janssen Pharmaceutical Companies of Johnson & Johnson

Curated by ChEMBL
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50:  12nMAssay Description:Inhibition of KHK (unknown origin) using D-fructose as substrate after 60 mins in presence of ATP by LC-MS analysisMore data for this Ligand-Target Pair
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKetohexokinase(Human)
Janssen Pharmaceutical Companies of Johnson & Johnson

Curated by ChEMBL
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50:  12nMAssay Description:Inhibition of human ketohexokinase isoform C expressed in Escherichia coli BL21 (DE3) cells using D-fructose as substrate after 12 to 15 mins by fluo...More data for this Ligand-Target Pair
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKetohexokinase(Human)
Janssen Pharmaceutical Companies of Johnson & Johnson

Curated by ChEMBL
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50: <500nMAssay Description:Inhibition of recombinant human hepatic KHKCMore data for this Ligand-Target Pair
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of IRAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKetohexokinase(Human)
Janssen Pharmaceutical Companies of Johnson & Johnson

Curated by ChEMBL
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50:  400nMAssay Description:Inhibition of human ketohexokinase isoform C expressed in Escherichia coli BL21 (DE3) cells using D-fructose as substrate after 12 to 15 mins by fluo...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of ABL1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivin receptor type-1B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of ALK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of AMPKA1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of AMPKB1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of AMPKG1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CAMK1DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CHK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform delta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CK1deltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDeath-associated protein kinase 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of DAPK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of EPHB1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of GSK3betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of INSRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of p38deltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase 26(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of MST4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of NEK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of NTRK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of PAK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of PDGFRBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of PIM2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of PLK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of PRKACAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of PKCthetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of ROCK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of RPS6KA3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CAMK2AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed