BDBM50387945 CHEMBL2058927::US9283222, 511

SMILES Fc1ccc(Cc2n[nH]c(=O)c3CCCNc23)cc1C(=O)N1CCN(CC1)c1cnccn1

InChI Key InChIKey=YPTKEKWQKTUVGP-UHFFFAOYSA-N

Data  2 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50387945   

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbvie

US Patent
LigandPNGBDBM50387945(CHEMBL2058927 | US9283222, 511)
Affinity DataKi:  0.400nMpH: 8.0Assay Description:PARP1 assay was conducted in PARP assay buffer containing 50 mM Tris pH 8.0, 1 mM DTT, 4 mM MgCl2. PARP reactions contained 1.5 uM [3H]-NAD+ (1.6 uCi...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetPoly [ADP-ribose] polymerase 1(Human)
Abbvie

US Patent
LigandPNGBDBM50387945(CHEMBL2058927 | US9283222, 511)
Affinity DataKi:  0.400nMAssay Description:Inhibition of PARP1 using [3H]NAD+ after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbvie

US Patent
LigandPNGBDBM50387945(CHEMBL2058927 | US9283222, 511)
Affinity DataEC50:  3.30nMAssay Description:Inhibition of PARP1 in H202-stimulated human C41 cells incubated for 30 mins prior to H2O2-treatment measured after 10 mins by FITC-based immunostain...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed