BDBM50390404 CHEMBL2070936

SMILES Fc1ccc(cc1)N1CCN(CC1)C(=O)[C@@H]1CCCC[C@H]1C(=O)NC1(CC1)C#N

InChI Key InChIKey=GHDIYQHGVKVLJX-RTBURBONSA-N

Data  10 IC50

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50390404   

TargetCathepsin K(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50390404(CHEMBL2070936)
Affinity DataIC50:  15nMAssay Description:Inhibition of human recombinant cathepsin-k using Z-Phe-Arg-AMC as substrate preincubated for 15 mins measured after 1 hr by QFRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetCathepsin K(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50390404(CHEMBL2070936)
Affinity DataIC50:  15nMAssay Description:Inhibition of cathepsin-kMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetProcathepsin L(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50390404(CHEMBL2070936)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant cathepsin-L using Z-Phe-Arg-AMC as substrate preincubated for 15 mins measured after 1 hr by QFRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin B(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50390404(CHEMBL2070936)
Affinity DataIC50:  1.09E+3nMAssay Description:Inhibition of human recombinant cathepsin-B using Z-Arg-Arg-AMC as substrate preincubated for 15 mins measured after 1 hr by QFRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin K(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50390404(CHEMBL2070936)
Affinity DataIC50:  15.8nMAssay Description:Inhibition of human recombinant cathepsin K using Z-Phe-Arg-AMC as substrate preincubated for 30 mins measured after 1 hr by quenched fluorescent res...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetProcathepsin L(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50390404(CHEMBL2070936)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant cathepsin L using Z-Phe-Arg-AMC as substrate preincubated for 30 mins measured after 1 hr by quenched fluorescent res...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin S(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50390404(CHEMBL2070936)
Affinity DataIC50:  1.26E+3nMAssay Description:Inhibition of human recombinant cathepsin S using Z-Val-Val-Arg-AMC as substrate preincubated for 30 mins measured after 1 hr by quenched fluorescent...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin B(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50390404(CHEMBL2070936)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human recombinant cathepsin B using Z-Arg-Arg-AMC as substrate preincubated for 30 mins measured after 1 hr by quenched fluorescent res...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50390404(CHEMBL2070936)
Affinity DataIC50:  3.16E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin S(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50390404(CHEMBL2070936)
Affinity DataIC50:  1.31E+3nMAssay Description:Inhibition of human recombinant cathepsin-S using Z-Val-Val-Arg-AMC as substrate preincubated for 15 mins measured after 1 hr by QFRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed