BDBM50393079 CHEMBL2152855::US9040542, 23
SMILES CCNC(=O)Nc1nc2cc(c(F)c([C@H]3CCCO3)c2[nH]1)-c1cnc(nc1)C(C)(C)O
InChI Key InChIKey=BKUISYCLLXCBJV-CQSZACIVSA-N
Data 7 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 50393079
Affinity DataKi: 9nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase using pBR322 plasmid DNA as substrate by coupled enzyme reaction assayMore data for this Ligand-Target Pair
Affinity DataKi: 9nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase Gyr B subunit by ATPase assayMore data for this Ligand-Target Pair
Affinity DataKi: 9nMpH: 7.6Assay Description:The ATP hydrolysis activity of S. aureus DNA gyrase is measured by coupling the production of ADP through pyruvate kinase/lactate dehydrogenase to th...More data for this Ligand-Target Pair
TargetDNA topoisomerase 4 subunit B(Staphylococcus aureus (strain NCTC 8325 / PS 47))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataKi: 12nMAssay Description:Inhibition of Staphylococcus aureus DNA topoisomerase 4 Par E subunit by ATPase assayMore data for this Ligand-Target Pair
TargetDNA topoisomerase 4 subunit A/B(Staphylococcus aureus (strain NCTC 8325 / PS 47))
Vertex Pharmaceuticals
US Patent
Vertex Pharmaceuticals
US Patent
Affinity DataKi: 12nMAssay Description:The conversion of ATP to ADP by S. aureus TopoIV enzyme is coupled to the conversion of NADH to NAD+, and the progress of the reaction is measured by...More data for this Ligand-Target Pair
Affinity DataKi: <21nMAssay Description:Inhibition of Staphylococcus aureus DNA gyraseMore data for this Ligand-Target Pair
Affinity DataKi: 28nMAssay Description:Inhibition of Staphylococcus aureus DNA topoisomerase 4More data for this Ligand-Target Pair