BDBM50393334 CHEMBL2152126

SMILES CC(C)c1ccc(cc1)-c1nccnc1N1CCN(CC1)S(=O)(=O)c1cccc(c1)-c1cnc(N)nc1

InChI Key InChIKey=IVXKQJAJTVBVLV-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50393334   

LigandPNGBDBM50393334(CHEMBL2152126)
Affinity DataIC50:  18nMAssay Description:Inhibition of human PI3Kgamma expressed in sf9 cells assessed as amount of ATP consumed by luciferase-luciferin chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM50393334(CHEMBL2152126)
Affinity DataIC50:  505nMAssay Description:Inhibition of human PI3Kalpha expressed in sf9 cells coexpressing p85alpha assessed as amount of ATP consumed by luciferase-luciferin chemiluminescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50393334(CHEMBL2152126)
Affinity DataIC50:  182nMAssay Description:Inhibition of human PI3Kgamma expressed in C5a-stimulated mouse RAW 264.7 cells assessed as inhibition of AKT phosphorylation by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM50393334(CHEMBL2152126)
Affinity DataIC50:  816nMAssay Description:Inhibition of human PI3Kdelta expressed in sf9 cells coexpressing p85alpha assessed as amount of ATP consumed by luciferase-luciferin chemiluminescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50393334(CHEMBL2152126)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human PI3Kbeta expressed in sf9 cells coexpressing p85alpha assessed as amount of ATP consumed by luciferase-luciferin chemiluminescenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed