BDBM50393851 CHEMBL1221983

SMILES CN[C@H]1CC[C@@H](CC1)N(Cc1cccc(c1)-c1ccncc1)C(=O)c1sc2ccccc2c1Cl

InChI Key InChIKey=VFSUUTYAEQOIMW-YHBQERECSA-N

Data  4 EC50

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50393851   

TargetSmoothened homolog(Mouse)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50393851(CHEMBL1221983)
Affinity DataEC50:  130nMAssay Description:Agonist activity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast incubated for 6 days by alkaline phosp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetSmoothened homolog(Mouse)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50393851(CHEMBL1221983)
Affinity DataEC50:  17nMAssay Description:Agonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetSonic hedgehog protein(Mouse)
Universit£T Leipzig

Curated by ChEMBL
LigandPNGBDBM50393851(CHEMBL1221983)
Affinity DataEC50:  8.80nMAssay Description:Activation of Shh pathway in mouse Shh-Light II cells assessed as induction of gli1 expression after 48 hrs by renilla luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSmoothened homolog(Mouse)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50393851(CHEMBL1221983)
Affinity DataEC50:  30nMAssay Description:Agonist activity at Smo in mouse NIH/3T3 cells transfected with Gli-dependent firefly luciferase reporter assessed as stimulation of Gli transcriptio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)