BDBM50394780 CHEMBL2163393

SMILES Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4CC[C@H](C4)C(=O)Nc4ccc(F)cc4)cc3)nn3cccc23)n[nH]1

InChI Key InChIKey=AYHJBFRPPDPHQD-LJQANCHMSA-N

Data  1 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50394780   

TargetAurora kinase B(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50394780(CHEMBL2163393)
Affinity DataKd:  6.90nMAssay Description:Binding affinity to Aurora kinase B catalytic domain by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase A(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50394780(CHEMBL2163393)
Affinity DataKd:  20nMAssay Description:Inhibition of Aurora kinase A autophosphorylation in human HEK293 cells after 2 hrs by phosphor antibody readout assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase B(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50394780(CHEMBL2163393)
Affinity DataIC50:  42nMAssay Description:Inhibition of Aurora kinase B-mediated histone H3 Ser10 phosphorylation in human HCT116 cells after 2 hrs by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed