BDBM50394820 CHEMBL2163829

SMILES CN1CCN(CC1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1(CC1)c1ccc(Cl)cc1Cl

InChI Key InChIKey=WFRXEZYSVYRRFE-QHCPKHFHSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50394820   

TargetCytochrome P450 3A4(Human)
Exelixis

Curated by ChEMBL
LigandPNGBDBM50394820(CHEMBL2163829)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human CYP3A4 using testosterone as substrate after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCeramide glucosyltransferase(Human)
Exelixis

Curated by ChEMBL
LigandPNGBDBM50394820(CHEMBL2163829)
Affinity DataIC50:  2nMAssay Description:Inhibition of GCS assessed as amount of UDP glucose after 3 hrs by Fluorometry analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCeramide glucosyltransferase(Human)
Exelixis

Curated by ChEMBL
LigandPNGBDBM50394820(CHEMBL2163829)
Affinity DataIC50:  10nMAssay Description:Inhibition of GCS assessed as amount of UDP glucose after 3 hrs by Fluorometry analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCeramide glucosyltransferase(Human)
Exelixis

Curated by ChEMBL
LigandPNGBDBM50394820(CHEMBL2163829)
Affinity DataIC50:  6nMAssay Description:Inhibition of GCS in human A549 cells assessed as decrease in GM1 synthesis after 72 hrs by Fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed