BDBM50396528 CHEMBL2171128

SMILES Nc1ncc(-c2cccnc2)c2scc(-c3ccc4N(CCc4c3)C(=O)Cc3ccccc3)c12

InChI Key InChIKey=VNDDOAWIHYNTOI-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50396528   

LigandPNGBDBM50396528(CHEMBL2171128)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of GST tagged PERK cytoplasmic domain mediated EIF2alpha phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50396528(CHEMBL2171128)
Affinity DataIC50: 15nMAssay Description:Inhibition of PERK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
LigandPNGBDBM50396528(CHEMBL2171128)
Affinity DataIC50: 100nMAssay Description:Inhibition of thapsigargin-induced autophosphorylation of PERK in human A549 cells after 2 hrs by Western blottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396528(CHEMBL2171128)
Affinity DataIC50: 457nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396528(CHEMBL2171128)
Affinity DataIC50: 741nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50396528(CHEMBL2171128)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PKR assessed as EIF2AK2 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50396528(CHEMBL2171128)
Affinity DataIC50: 1.21E+4nMAssay Description:Inhibition of HRI assessed as EIF2AK1 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed