BDBM50396530 CHEMBL2171133

SMILES Nc1nccc2scc(-c3ccc4N(CCc4c3)C(=O)Cc3ccccc3)c12

InChI Key InChIKey=ZDMNFWRMUCKWCS-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50396530   

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
Glaxosmithkline

Curated by ChEMBL

LigandBDBM50396530(CHEMBL2171133)Copy SMILESCopy InChI

Affinity DataIC50:  12nMAssay Description:Inhibition of GST tagged PERK cytoplasmic domain mediated EIF2alpha phosphorylationMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
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Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
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TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
Glaxosmithkline

Curated by ChEMBL

LigandBDBM50396530(CHEMBL2171133)Copy SMILESCopy InChI

Affinity DataIC50: >300nMAssay Description:Inhibition of thapsigargin-induced autophosphorylation of PERK in human A549 cells after 2 hrs by Western blottingMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI
Copy reaction URL

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
Glaxosmithkline

Curated by ChEMBL

LigandBDBM50396530(CHEMBL2171133)Copy SMILESCopy InChI

Affinity DataIC50: <15nMAssay Description:Inhibition of PERK (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails PubMedPDB3D Structure (crystal)
Copy BDB DOI
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TargetEukaryotic translation initiation factor 2-alpha kinase 1(Human)
Glaxosmithkline

Curated by ChEMBL

LigandBDBM50396530(CHEMBL2171133)Copy SMILESCopy InChI

Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of HRI assessed as EIF2AK1 phosphorylationMore data for this Ligand-Target Pair

Target InfoReactome pathwayKEGG
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
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TargetInterferon-induced, double-stranded RNA-activated protein kinase(Human)
Glaxosmithkline

Curated by ChEMBL

LigandBDBM50396530(CHEMBL2171133)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PKR assessed as EIF2AK2 phosphorylationMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI
Copy reaction URL