BDBM50396531 CHEMBL2171132

SMILES Cn1cc(cn1)-c1cnc(N)c2c(csc12)-c1ccc2N(CCc2c1)C(=O)Cc1ccccc1

InChI Key InChIKey=LIGGMBSSOOVGAE-UHFFFAOYSA-N

Data  5 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50396531   

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
Glaxosmithkline

Curated by ChEMBL

LigandBDBM50396531(CHEMBL2171132)Copy SMILESCopy InChI

Affinity DataIC50:  1.30nMAssay Description:Inhibition of GST tagged PERK cytoplasmic domain mediated EIF2alpha phosphorylationMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
Glaxosmithkline

Curated by ChEMBL

LigandBDBM50396531(CHEMBL2171132)Copy SMILESCopy InChI

Affinity DataIC50:  30nMAssay Description:Inhibition of thapsigargin-induced autophosphorylation of PERK in human A549 cells after 2 hrs by Western blottingMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

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In DepthDetails ArticlePubMed
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TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
Glaxosmithkline

Curated by ChEMBL

LigandBDBM50396531(CHEMBL2171132)Copy SMILESCopy InChI

Affinity DataIC50: <15nMAssay Description:Inhibition of PERK (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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In DepthDetails PubMed
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TargetEukaryotic translation initiation factor 2-alpha kinase 1(Human)
Glaxosmithkline

Curated by ChEMBL

LigandBDBM50396531(CHEMBL2171132)Copy SMILESCopy InChI

Affinity DataIC50:  1.86E+3nMAssay Description:Inhibition of HRI assessed as EIF2AK1 phosphorylationMore data for this Ligand-Target Pair

Target InfoReactome pathwayKEGG
UniProtKB/SwissProt
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TargetInterferon-induced, double-stranded RNA-activated protein kinase(Human)
Glaxosmithkline

Curated by ChEMBL

LigandBDBM50396531(CHEMBL2171132)Copy SMILESCopy InChI

Affinity DataIC50:  978nMAssay Description:Inhibition of PKR assessed as EIF2AK2 phosphorylationMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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