BDBM50397078 CHEMBL2171452

SMILES COc1ccc(cc1OCCCCOc1ccc(cc1)-c1nnn[nH]1)C1=NN(C2CCCCCC2)C(=O)C1(C)C

InChI Key InChIKey=JPXAIORZGBCHIB-UHFFFAOYSA-N

Data  4 KI  7 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50397078   

TargetDNA (cytosine-5)-methyltransferase 3A(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50397078(CHEMBL2171452)
Affinity DataKi:  3.70E+3nMAssay Description:Mixed type inhibition of human DNMT3A using AdoMet as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 3A(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50397078(CHEMBL2171452)
Affinity DataKi:  5.03E+3nMAssay Description:Binding affinity to human DNMT3A catalytic domain assessed as inhibition of enzyme-mediated DNA methylation using 3H-AdoMet as substrate incubated fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 3A(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50397078(CHEMBL2171452)
Affinity DataKi:  1.26E+4nMAssay Description:Mixed type inhibition of human DNMT3A using poly dl-dC as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 3A(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50397078(CHEMBL2171452)
Affinity DataKi:  2.16E+4nMAssay Description:Binding affinity to human DNMT3A catalytic domain assessed as inhibition of enzyme-mediated DNA methylation using poly dl-dC as substrate incubated f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50397078(CHEMBL2171452)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human PDE4A1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50397078(CHEMBL2171452)
Affinity DataIC50:  49nMAssay Description:Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50397078(CHEMBL2171452)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of human PDE4B1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50397078(CHEMBL2171452)
Affinity DataIC50:  10nMAssay Description:Inhibition of human PDE4C1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50397078(CHEMBL2171452)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human PDE4D3 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation proximity assayMore data for this Ligand-Target Pair
TargetPhosphodiesterase(Trypanosoma brucei)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50397078(CHEMBL2171452)
Affinity DataIC50:  55nMAssay Description:Inhibition of Trypanosoma brucei His-tagged catalytic domains of TbrPDEB1 expressed in Escherichia coli BL21 assessed as conversion of cAMP to AMP af...More data for this Ligand-Target Pair
TargetPhosphodiesterase(Leishmania major)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50397078(CHEMBL2171452)
Affinity DataIC50:  130nMAssay Description:Inhibition of Leishmania major recombinant PDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation proxim...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed