BDBM50397137 CHEMBL2172002

SMILES COc1ccc(nc1OC)N1CCN([C@H](C)C1)C(=O)[C@@H]1CCCC[C@H]1C(=O)NC1(CC1)C#N

InChI Key InChIKey=RZRSGESNYRZLJD-KZNAEPCWSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50397137   

TargetCathepsin B(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50397137(CHEMBL2172002)
Affinity DataIC50:  1.69E+3nMAssay Description:Inhibition of human recombinant cathepsin-B using Z-Arg-Arg-AMC as substrate preincubated for 15 mins measured after 1 hr by QFRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProcathepsin L(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50397137(CHEMBL2172002)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant cathepsin-L using Z-Phe-Arg-AMC as substrate preincubated for 15 mins measured after 1 hr by QFRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin K(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50397137(CHEMBL2172002)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant cathepsin-k using Z-Phe-Arg-AMC as substrate preincubated for 15 mins measured after 1 hr by QFRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin S(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50397137(CHEMBL2172002)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human recombinant cathepsin-S using Z-Val-Val-Arg-AMC as substrate preincubated for 15 mins measured after 1 hr by QFRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed